Fail-safe system may lead to cures for inherited disorders
Scientists at the University of California, San Diego School of Medicine have uncovered a previously unknown fail-safe (compensatory) pathway that potentially protects the brain and other organs from...
View ArticleParty drug's brain tricks explained for first time
(Medical Xpress) -- A researcher at the University of Sydney has discovered how the increasingly common street drug mephedrone affects the brain, helping to explain why it is potentially such an...
View ArticleNew medication offers hope to patients with frequent, uncontrollable seizures
A new type of anti-epilepsy medication that selectively targets proteins in the brain that control excitability may significantly reduce seizure frequency in people whose recurrent seizures have been...
View ArticleReach2HD, a Phase II study in Huntington's disease, launched
The Huntington Study Group (HSG), under the leadership of Ray Dorsey, M.D. with Johns Hopkins Medical and Diana Rosas, M.D. with Massachusetts General Hospital, is conducting a clinical trial in...
View ArticleDesigner compounds inhibit prion infection
(Medical Xpress) -- A team of University of Alberta researchers has identified a new class of compounds that inhibit the spread of malfunctioning proteins in the brain that cause lethal...
View ArticleMaking sense out of the biological matrix of bipolar disorder
The more that we understand the brain, the more complex it becomes. The same can be said about the genetics and neurobiology of psychiatric disorders. For "Mendelian" disorders, like Huntington...
View Article'Foreign' proteins are also implicated in Alzheimer's disease, implications...
Neurodegenerative diseases such as Alzheimer's or Parkinson's are characterised by the loss of nerve cells and the deposition of proteins in the brain tissue. A group of researchers led by Gabor G....
View ArticleEnzyme inhibition protects against Huntington's disease damage in two animal...
Treatment with a novel agent that inhibits the activity of SIRT2, an enzyme that regulates many important cellular functions, reduced neurological damage, slowed the loss of motor function and extended...
View ArticleFragile X protein linked to nearly 100 genes involved in autism
Doctors have known for many years that patients with fragile X syndrome, the most common form of inherited intellectual disability, are often also diagnosed with autism. But little has been known about...
View ArticleBrake on nerve cell activity after seizures discovered: Gene expression...
Given that epilepsy impacts more than 2 million Americans, there is a pressing need for new therapies to prevent this disabling neurological disorder. New findings from the neuroscience laboratory of...
View ArticleGreen tea extract interferes with the formation of amyloid plaques in...
Researchers at the University of Michigan have found a new potential benefit of a molecule in green tea: preventing the misfolding of specific proteins in the brain.
View ArticleScientists identify Buphenyl as a possible drug for Alzheimer's disease
(Medical Xpress)—Buphenyl, an FDA-approved medication for hyperammonemia, may protect memory and prevent the progression of Alzheimer's disease. Hyperammonemia is a life-threatening condition that can...
View ArticleNew chemical approach to treat Alzheimer's
Scientists at the University of Liverpool and Callaghan Innovation in New Zealand have developed a new chemical approach to help harness the natural ability of complex sugars to treat Alzheimer's disease.
View ArticleStudy of dietary intervention examines proteins in brain
The lipidation states (or modifications) in certain proteins in the brain that are related to the development of Alzheimer disease appear to differ depending on genotype and cognitive diseases, and...
View ArticleUndiagnosed pre-diabetes highly prevalent in early Alzheimer's disease study
When Georgetown University neurologist R. Scott Turner, MD, PhD, began enrolling people with mild to moderate Alzheimer's disease into a nationwide study last year, he expected to find only a handful...
View ArticlePath of plaque buildup in brain shows promise as early biomarker for...
The trajectory of amyloid plaque buildup—clumps of abnormal proteins in the brain linked to Alzheimer's disease—may serve as a more powerful biomarker for early detection of cognitive decline rather...
View ArticleCopper identified as culprit in Alzheimer's disease
Copper appears to be one of the main environmental factors that trigger the onset and enhance the progression of Alzheimer's disease by preventing the clearance and accelerating the accumulation of...
View ArticleNot guility: Parkinson and protein phosphorylation
Clues left at the scene of the crime don't always point to the guilty party, as EPFL researchers investigating Parkinson's disease have discovered. It is generally accepted that the disease is...
View ArticleRare brain disease concerns in US after death
Public health officials believe one person in the U.S. has died of a rare, degenerative brain disease, and they say there's a remote chance up to 13 others in multiple states were exposed to the fatal...
View ArticleNewly identified antibodies effectively treat Alzheimer's-like disease in mice
Alzheimer's disease is characterized by the accumulation of particular toxic proteins in the brain that are believed to underlie the cognitive decline in patients. A new study conducted in mice...
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